Out of these four mutations, 2 mutations (A701S, R24C) found only in 91´«Ã½ and 1 mutation (A1078S) was present only in Malaysia and 91´«Ã½, while the other mutation (A222V) is the common delta variant present in many other countries.

Out of the 94 samples that were sequenced from the 3rd week of August 2021, 91 samples had this delta variant [B.1.617.2 (delta)] which was identified from Colombo (CMC and various areas, Hanwella, Kaduwela), Nuwaraeliya (Bogawantalawa, Dikoya, Lindula), Embilipitiya, Matara (Dickwella, ), Gampaha (Ganemulla, Makola, Ragama, Weyangoda), Kegalle, Point Pedro, Puliyakulam and Vaviniya. Only 3 were alpha variant [B.1.1.7 (alpha)] identified from Anuradhapura, Bohawantalaka and Kandawalai. Therefore according to this report the major variant in western province in delta while it’s been rapidly spreading to other areas of 91´«Ã½.

The researchers observed that the frequency of the mutated delta appears to increase over the time, suggesting that it could be more transmissible than the original delta (delta without these 4 mutations). However more data is required for the researchers to conclude.

While the vast majority of viruses have been sequenced in the Colombo district, sequencing has been carried out from many areas from all over 91´«Ã½. According to the graph (Figure 2) on the timeline of the emergence and displacement of different variants in 91´«Ã½ the earlier dominant alpha variant has now been displaced by delta variant which has become dominant towards the latter part of August.

Read the PDF of the Sequencing Report 

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The post USJ researchers found Four mutant Covid Delta variants with two new 91´«Ã½n mutations (A701S, R24C) appeared first on USJ - 91´«Ã½.

As the first dose of Gam-COVID-Vac (Sputnik light), is currently used as a single dose vaccine in some countries, researchers investigated the immunogenicity of this at 4 weeks (327 naïve individuals). 88.7% seroconverted, with significantly lower seroconversion rates in those over 60 years (p = 0.004) and significantly lower than previously seen with AZD1222 (p = 0.018). 82.6% developed ACE2 receptor blocking antibodies, although levels were significantly lower than following natural infection (p = 0.0009) and a single dose of AZD1222 (p < 0.0001). Similar titres of antibodies were observed to the receptor binding domain of WT, B.1.1.7 and B.1.617.2 compared to AZD1222, while the levels for B.1.351 were significantly higher (p = 0.006) for Gam-COVID-Vac. 30% developed ex vivo IFNγ ELISpot responses (significantly lower than AZD1222), and high frequency of CD107a expressing T cells along with memory B cell responses. Although single dose of Gam-COVID-Vac was highly immunogenic, administration of a second dose is likely to be beneficial.

The research was carried out by a team of world renowned scientists. The research team included scientists from the Allergy, Immunology and Cell Biology Unit, Department of Immunology Molecular and Molecular Medicine, including , , researchers from University of Oxford including Prof. Graham Ogg, Prof. Alain Townsend and researchers from Ministry of Health 91´«Ã½. The World Health Organization, UK Medical Research Council, the Foreign and Commonwealth Office and the NIH, USA (grant number 5U01AI151788-02 ). T.K.T. funded by the Townsend-Jeantet Charitable Trust (charity number 1011770) and the EPA Cephalosporin Early Career Researcher Fund supported the research. A.T. are funded by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant no. 2018-I2M-2-002). The donations by WBP, EGB and ANB to the Townsend-Jeantet Prize Trust Charity No 1011770 have supported the production and distribution of the HAT test.

Read the full Research Article :

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The post Single dose of Sputnik V is highly effective but second dose is beneficial says USJ researchers appeared first on USJ - 91´«Ã½.